Roles of multiple oxidized LDL lipids in cellular injury: dominance of 7 beta-hydroperoxycholesterol

Roles of multiple oxidized LDL lipids in cellular injury: dominance of 7 beta-hydroperoxycholesterol.

The relative toxicities of several lipid oxidation products formed on oxidized LDL, their presence on oxidized LDL, and potential mechanisms of cell injury compared to oxidized LDL were examined. Toxicities to fibroblasts, with lipoprotein-deficient serum supplementation, were: 7 beta-hydroperoxycholesterol > 7 beta-hydroxycholesterol = 4-hydroxynonenal > 7-ketocholesterol > 5 alpha, 6 alpha-ep...

Roles of Dietary Lipids in Development of Atherosclerosis: LDL

Oxidized Ldl Lipids as a Risk Factor for Atherosclerosis

In vitro cell injury by oxidized low density lipoprotein involves lipid hydroperoxide-induced formation of alkoxyl, lipid, and peroxyl radicals.

Mounting evidence supports current theories linking lipoprotein oxidation to atherosclerosis. We sought the cellular biochemical mechanism by which oxidized LDL inflicts cell injury. Inhibitors of candidate pathways of cell death were used to treat human fibroblast target cells exposed to oxidized LDL.. Ebselen, which degrades lipid hydroperoxides, inhibited oxidized LDL toxicity, consistent wi...

Lectin-like oxidized LDL receptor-1: Its diverse roles beyond an oxidized LDL receptor and clinical relevance

Oxidative stress induced by reactive oxygen species (ROS) plays an important role in the pathogenesis of various cardiovascular diseases. The redox state is determined by the balance between the pro-oxidative and anti-oxidative systems, and its imbalance leads to oxidative stress. ROS directly induces endothelial injury and inactivates endotheliumderived nitric oxide, which is a potent protecti...